We are currently recruiting highly motivated and qualified Post-Doctoral Scientists who are excited about science and keen to discover and tackle a new area of research: Novel DNA and RNA modifications in the brain. Critical thinking, troubleshooting skills, developing own ideas, keen on learning, ability to work independently and collaboratively are essential. Post-Doctoral Scientists must hold a PhD degree.
We are keen to recruit multiple Post-Doctoral Scientists that address various fundamental biological questions:
- Where do novel DNA/RNA modifications occur within the genome/transcriptome and what is their function? The project involves the use of computational methods, such as PacBio/SMRT-Seq/MinION, to identify and study DNA and RNA modifications such as methylated deoxyadenosines within human and mouse genomes. The candidate should have demonstrable experience in data analysis from the Illumina sequencing platform. Experience in ChIP-Seq, RNA-Seq data analysis and knowledge of R for statistics is an advantage.
- How are DNA/RNA modifications distributed in healthy and diseased brains? Can we identify currently undiscovered DNA/RNA modifications in the brain? This project involves the systematic identification of DNA and RNA modifications in human/mouse brains by mass spectrometry. The candidate should be well organized, thorough and be interested in mass spectrometry. Experience with liquid chromatography, mass spectrometry or chemistry is an advantage, but is not a prerequisite.
- What are the unknown molecular mechanisms that regulate DNA/RNA modifications and what is their role? The project will discover and allow us to study molecules and pathways that regulate DNA/RNA modifications in human and mouse neuronal cells. The candidate should possess a solid background in molecular biology/biochemistry.
- How do How do DNA/RNA modifications effect neuron and brain function? The goal of this project is to investigate the function of novel DNA/RNA modifications and their interacting proteins in the mouse brain. Prior experience with mice or in the field of neurobiology is an advantage.
The above projects are essential for understanding the ‘building blocks of human life’, namely DNA and RNA. They also set the basis for developing novel therapies for diseases of the human brain. In addition to the above questions, we of course always welcome applications with their own project ideas and collaborations.
The Post-Doctoral Scientist will be paid RMB 280k-350k (~40k-52k US$) per year, depending on experience and qualifications. In addition, generous insurance and welfare benefits will be provided for all CIBR employees. Earliest starting date is 1stJune 2019.
DOCUMENTS FOR APPLICATIONS
All applicants should email the application documents directly to Magdalena Koziol. The application should contain the following:
- Cover Letter – please indicate which position you are applying for and your interests
- CV – including contact details of at least 2 referees